Deltarasin (hydrochloride)
CAS No. : 1613404-76-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $252 | In-stock |
| 50mg | $1008 | In-stock |
| 100mg | $1800 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15747A |
| M.Wt: | 640.22 |
| Formula: | C40H38ClN5O |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : ≥ 52 mg/mL |
Deltarasin hydrochloride is an inhibitor of?KRAS-PDEδinteraction with?Kd?of 38 nM for binding to purified PDEδ. IC50 & Target: Kd: 38 nM (PDEδ) In Vitro: In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with KD?of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS[1]. In Vivo: Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts[1].
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