Tuvusertib
CAS No. : 1613200-51-3
(Synonyms: M1774; ATR inhibitor 1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $970 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111451 |
| M.Wt: | 370.32 |
| Formula: | C16H12F2N8O |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ[1].
IC50 & Target:Ki: less than 1 uM[1]
In Vitro: Tuvusertib (0-2 μM, 24 h) induces cell death and cell apoptosis in myeloma cells (such as U266 and OPM2 cells)[2].
Tuvusertib (0-5 μM, 16 or 24 h) inhibits STAT3 p-Y705 phosphorylation and down-regulates STAT3 downstream targets (c-MYC) in U266 and OPM2 cells[2].
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