Amotosalen
CAS No. : 161262-29-9
(Synonyms: S-59 (free base))
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| Cat. No. : | HY-107004 |
| M.Wt: | 301.34 |
| Formula: | C17H19NO4 |
| Purity: | >98 % |
| Solubility: |
Amotosalen (S-59 (free base)) is a light-activated, DNA and RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD)[1][2]. In Vitro:When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].
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