Burosumab


CAS No. : 1610833-03-8

(Synonyms: KRN23; N5KG1_C10_LH; UX-023)

1610833-03-8
Price and Availability of CAS No. : 1610833-03-8
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1mg $260 In-stock
5mg $600 In-stock
10mg $960 In-stock
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Cat. No. : HY-P9939
M.Wt: 1000.00
Formula: N/A
Purity: >98 %
Solubility: H2O
Introduction of 1610833-03-8 :

Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia[1][2][3]. IC50 & Target:FGF23[1] In Vivo:Burosumab (4-16 mg/kg; subcutaneous injection; once weekly; 2 months) has a beneficial effect on alveolar bone tissue in a mouse model of X-linked hypophosphatemia[3].

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