KDU731
CAS No. : 1610610-48-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $460 | In-stock |
| 25mg | $930 | In-stock |
| 50mg | $1500 | In-stock |
| 100mg | $2400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103583 |
| M.Wt: | 396.40 |
| Formula: | C22H16N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2]. IC50 & Target: IC50: 25 nM (C. parvum PI4K)[2] In Vivo: KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2]. KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2].
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