NU2058
CAS No. : 161058-83-9
(Synonyms: O6-(Cyclohexylmethyl)guanine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $29 | In-stock |
| 10mg | $44 | In-stock |
| 25mg | $88 | In-stock |
| 50mg | $133 | In-stock |
| 100mg | $200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19316 |
| M.Wt: | 247.30 |
| Formula: | C12H17N5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL |
NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity. In Vitro: NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
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