(±)-Enitociclib (Standard)
CAS No. : 1610358-53-6
(Synonyms: (±)-BAY-1251152 (Standard); (±)-VIP152 (Standard))
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| Cat. No. : | HY-103019AR |
| M.Wt: | 404.43 |
| Formula: | C19H18F2N4O2S |
| Purity: | >98 % |
| Solubility: |
(±)-Enitociclib (Standard) is the analytical standard of (±)-Enitociclib (HY-103019A). This product is intended for research and analytical applications. (±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies[1][2].
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