Peptide T (TFA)
CAS No. : 1610056-01-3
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| Cat. No. : | HY-P0272A |
| M.Wt: | 971.89 |
| Formula: | C37H56F3N9O18 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. IC50 & Target:CD4, HIV[1] In Vitro: Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3]. In Vivo: Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].
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