TH588
CAS No. : 1609960-31-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $168 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $528 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-12814 |
| M.Wt: | 295.17 |
| Formula: | C13H12Cl2N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16 mg/mL (ultrasonic;warming) |
TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). IC50 & Target: IC50: 5 nM (MTH1)[1] In Vitro: TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM[1]. In Vivo: TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1].
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