Ziv-aflibercept
CAS No. : 1609655-49-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $380 | In-stock |
| 10mg | $620 | In-stock |
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| Cat. No. : | HY-108798 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2]. In Vitro: Ziv-aflibercept (0.25, 0.5, 1.0 and 5 mg/mL; 24 h) reduces mitochondrial membrane potential in ARPE-19 cells with dose dependent manner[1]. In Vivo: Ziv-aflibercept (25 mg/mL; intravitreal injection; single dose) insignificantly causes cataract, retinal detachment and other related complications in the right eye of the rabbit[2].
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