PF-06256142
CAS No. : 1609583-14-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $320 | In-stock |
| 10mg | $545 | In-stock |
| 25mg | $1080 | In-stock |
| 50mg | $1760 | In-stock |
| 100mg | $2720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119943 |
| M.Wt: | 356.38 |
| Formula: | C21H16N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease[1].
In Vitro: PF-06256142 exhibits IC50 values of <5 μM as an antagonist at the following 4 targets: M1 (4.9 μM); CB1 (2.1 μM); H1 (4.6 μM); Nav 1.5 (1.1 μM)[1].
PF-06256142 has an IC50 of approximately 12 μM for hERG[1].
PF-06256142 shows a Ki of 4.8 nM for D5 exquisitely selective than D2 (Ki>10 μM)[1].
In Vivo: PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg)[1].
PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg)[1].
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