DY268
CAS No. : 1609564-75-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $950 | In-stock |
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| Cat. No. : | HY-110267 |
| M.Wt: | 560.66 |
| Formula: | C30H32N4O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM. DY268 can be used in the study of drug-induced liver injury (DILI)[1][2].
In Vitro:DY268 (10 μM) treatment from 13 dpf to 15 dpf increased Bhmt expression in 15-dpf Tg(fabp10a:pt-β-catenin) livers compared with DMSO treatment[2].
DY268 exhibits a>25% drop in ATP relative to vehicle-treated control at the highest concentration tested[3].
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