PF2562
CAS No. : 1609258-91-4
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| Cat. No. : | HY-120879 |
| M.Wt: | 331.37 |
| Formula: | C19H17N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay[1].
IC50 & Target: EC50: 568 nM (human D1 cAMP)[1]
Ki: 113 nM (human D1 receptor)[1]
In Vitro: Dopamine acts upon neurons through two families of dopamine receptors, D1-like receptors (D1Rs) and D2-like receptors (D2Rs). The D1-like receptor family consists of D1 and D5 receptors which are expressed in many regions of the brain. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions[1].
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