Auristatin E
CAS No. : 160800-57-7
| Size | Price | Stock |
|---|---|---|
| 50mg | $55 | In-stock |
| 100mg | $90 | In-stock |
| 250mg | $170 | In-stock |
| 500mg | $270 | In-stock |
| 1g | $430 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-15582 |
| M.Wt: | 732.01 |
| Formula: | C40H69N5O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids[1][2][3].
In Vitro:Auristatin E (1-10000 nM, 2 h) shows the cytotoxic effects on L2987 human lung adenocarcinoma cells and various hematologic cell lines[2].
In Vivo:Auristatin E (0.25 mg/kg, s.c., a single dose for 80 days) inhibits tumor growth in nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts[2].
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