Upadacitinib (tartrate tetrahydrate)
CAS No. : 1607431-21-9
(Synonyms: ABT-494 (tartrate tetrahydrate))
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| Cat. No. : | HY-19569A |
| M.Wt: | 602.52 |
| Formula: | C17H19F3N6O.C4H6O6.4H2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research[1][2]. In Vitro: In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1]. In Vivo: Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models[3].
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