CP 141938
CAS No. : 160503-02-6
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| Cat. No. : | HY-10047 |
| M.Wt: | 403.54 |
| Formula: | C21H29N3O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].
In Vitro:Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM) decreases the basal activity of H214A (constitutively active mutant of T2R4) by 40%[1].
Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 mins) blocks the decrease of basal activation state of Rac1 caused by Quinine (HY-D0143) in HEK293T cells overexpressing T2R4 and Ga16/44, but has no effect in HEK293T control cells[2].
In Vivo:Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) has no effect on lick responses to bitter compounds in adult C57BL6/J mice[3].
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