AK 295
CAS No. : 160399-35-9
(Synonyms: CX 295)
| Size | Price | Stock |
|---|---|---|
| 1mg | $410 | In-stock |
| 5mg | $1020 | In-stock |
| 10mg | $1680 | In-stock |
| 25mg | $3360 | In-stock |
| 50mg | $5380 | In-stock |
| 100mg | $8600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119378 |
| M.Wt: | 504.62 |
| Formula: | C26H40N4O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis[1][2][3].
IC50 & Target:Calpain[1].
In Vitro:AK 295 (100 μM) inhibits the activity of the cysteine protease calpain in reovirus-infected primary cardiac myocytes[3].
In Vivo:AK 295 (2 mg/kg, i.p., 1 hour after trauma) inhibits apoptosis and improves neurologic function in rats with spinal cord trauma[1].
AK 295 (0.3-3 mg/kg, through the internal carotid artery, beginning 1.25 h from occlusion) protects against ischemic brain damage in stroke rats models[2].
AK 295 (70 mg/kg, i.p., once a day for 6 times) reduces reovirus myocarditis in reovirus strain 8B infection of neonatal mice[3].
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