TX2-121-1
CAS No. : 1603845-42-6
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| Cat. No. : | HY-118998 |
| M.Wt: | 716.91 |
| Formula: | C42H52N8O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TX2-121-1 is a potent and selective Her3 (ErbB3) degrader that contains a hydrophobic adamantane moiety. TX2-121-1 has an IC50 of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors. (Pink: Her3 inhibitor (HY-164988); Black: Linker; Blue: Adamantane (HY-N2427))[1].
In Vitro:TX2-121-1 (1-5 μM; 12 h) induces Her3 degradation, inhibits the phosphorylation of downstream Erk and Akt and cell proliferation in PC9 GR4 cells[1].
TX2-121-1 (1 μM; 6 h) interferes with the heterodimerization of Her3 with Her2 and c-Met in PC9 GR4 cells[1].
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