Nelipepimut-S
CAS No. : 160212-35-1
(Synonyms: E75)
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| Cat. No. : | HY-106204 |
| M.Wt: | 995.21 |
| Formula: | C50H78N10O11 |
| Purity: | >98 % |
| Solubility: | H2O |
Nelipepimut-S (E75) is a peptide vaccine targeting HER2. When used in combination with granulocyte-macrophage colony-stimulating factor, Nelipepimut-S stimulates immune activity and induces anti-HER2 immune responses. Nelipepimut-S can be used in research related to breast cancer, triple-negative breast cancer and ductal carcinoma in situ[1][2].
In Vitro:Nelipepimut-S acts as the HLA-A2 immunodominant epitope of HER2, potently stimulating cell lysis by ovarian cancer reactive CTL lines and demonstrating high HLA-A2 stabilizing ability[2].
Nelipepimut-S is presented on HLA-A2 in ovarian cancer cell lines and is recognized by ovarian cancer-associated CD8+ T-cell clones[2].
In Vivo:Nelipepimut-S elicits a HER2-specific CTL response that mediates in vivo lysis of HER2-expressing tumor cells in transgenic mice[2].
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