2-Iminopiperidine (hydrochloride)
CAS No. : 16011-96-4
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| Cat. No. : | HY-101328A |
| M.Wt: | 134.61 |
| Formula: | C5H11ClN2 |
| Purity: | >98 % |
| Solubility: |
2-Iminopiperidine (compound 13) hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine (hydrochloride) can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases[1].
In Vitro:2-Iminopiperidine (compound 13) hydrochloride (15 minute) inhibits mouse inducible nitric oxide synthase (IC50 = 0.6 μM) and rat brain constitutive nitric oxide synthase (IC50 = 2.0 μM) in vitro[1].
2-Iminopiperidine (1h pre-incubation on ice; 1h incubation at 37°C) inhibits nitrite production by LPS-induced RAW 264.7 cells (IC50 = 14 μM) in vitro[1].
In Vivo:2-Iminopiperidine (compound 13) hydrochloride (1-100 mg/kg; p.o.) inhibits LPS-induced nitric oxide production in rats, with an ED50 of 3.4 mg/kg when administered orally[1].
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