SCH 58261
CAS No. : 160098-96-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $740 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19533 |
| M.Wt: | 345.36 |
| Formula: | C18H15N7O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively[1][2][3].
IC50 & Target: IC50: 15 nM (A2A receptor)[2]
In Vitro: SCH 58261 (0 nM–10 µM; 7 days) decreases cell viability in a concentration-dependent in the NSCLC cell line H1975[4].
SCH58261 (25 μM; 72 hours) can inhibit the growth of CAF cells[5].
In Vivo: SCH 58261 (2 mg/kg; i.p.; daily; for 20 days) causes a decrease in the tumor burden in a NSCLC mouse model[5].
SCH 58261 (5 mg/kg; i.p.; 3 times; every 3 hours; 10 minutes before haloperidol) partially decreases the haloperidol-induced catalepsy and the increase in the PENK mRNA expression in both dorsolateral and ventrolateral parts of the striatum at all three examined levels[6].
SCH 58261 diminishes the parkinsonian-like muscle rigidity and potentiates the effect of L-DOPA in rat model[7].
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