Tilfrinib
CAS No. : 1600515-49-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $170 | In-stock |
| 50mg | $590 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110244 |
| M.Wt: | 275.30 |
| Formula: | C17H13N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].
IC50 & Target:IC50: 3.15 nM (Brk), PTK6[1][2].
In Vitro:Tilfrinib (20 µM; 36 h) shows inhibition of PTK6, and decreases the ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs[1].
Tilfrinib (compound 4f) shows good anti-proliferative activity against MCF7, HS-578/T and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 µM[2].
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