Size | Price | Stock |
---|---|---|
5mg | $750 | In-stock |
10mg | $1200 | In-stock |
25mg | $2400 | In-stock |
50mg | $3840 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
We match the lowest price on market. |
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Cat. No. : | HY-100342 |
M.Wt: | 1097.37 |
Formula: | C56H80N12O9S |
Purity: | >98 % |
Solubility: | DMSO : 50 mg/mL (45.56 mM; Need ultrasonic) |
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK. IC50 & Target: IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)[1] In Vitro: Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells[1].
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