Adrenomedullin (AM) (22-52), human
CAS No. : 159899-65-7
(Synonyms: 22-52-Adrenomedullin (human))
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| Cat. No. : | HY-P1471 |
| M.Wt: | 3575.98 |
| Formula: | C159H252N46O48 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1][2].
IC50 & Target:Adrenomedullin receptor, CGRP receptor[1]
In Vitro: Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells[1].
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