EPZ011989
CAS No. : 1598383-40-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $99 | In-stock |
| 50mg | $308 | In-stock |
| 100mg | $495 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16986 |
| M.Wt: | 605.81 |
| Formula: | C35H51N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
EPZ011989 is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ011989 has inhibitory inhibition for EZH2 with a Ki value of <3 nM. EPZ011989 shows robust methyl mark inhibition and anti-tumor activity. EPZ011989 can be used for the research of various cancers[1]. EPZ011989 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC50 & Target:Ki: <3 nM (EZH2); IC50: 94 nM (H3K27 methylation inhibition)[1].
In Vitro:EPZ011989 inhibits mutant and wild-type EZH2 with an Ki value of <3 nM[1].
EPZ011989 reduces cellular H3K27 methylation with an IC50 value of 94 nM[1].
EPZ011989 (0-10 μM; 11 days) has anti-proliferation effect in WSU-DLCL2 cells[1].
In Vivo:EPZ011989 (oral; 30-1000 mg/kg; single or bid; for 7 days or 21 days) can elicit robust methyl mark inhibition and antitumor activity[1].
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