Cemadotin
CAS No. : 159776-69-9
(Synonyms: LU103793 (free base))
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| Cat. No. : | HY-13589 |
| M.Wt: | 640.86 |
| Formula: | C35H56N6O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1][2].
IC50 & Target:Ki: 1 μM (tubulin)[1]
In Vitro:Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus[1].
Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration[1].
Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency[1].
Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60[2].
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