Linetastine


CAS No. : 159776-68-8

159776-68-8
Price and Availability of CAS No. : 159776-68-8
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Cat. No. : HY-123103
M.Wt: 584.70
Formula: C35H40N2O6
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 159776-68-8 :

Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes[1]. In Vivo:Linetastine inhibits histamine-induced bronchoconstriction dose-dependently at 1-10 mg/kg (p.o.) in guinea-pigs, and the effect lasts for more than 24 h[1].

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