BRD1172
CAS No. : 1597438-86-2
(Synonyms: ML320)
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| Cat. No. : | HY-120917 |
| M.Wt: | 391.39 |
| Formula: | C20H20F3N3O2 |
| Purity: | >98 % |
| Solubility: |
BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC50 of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research[1].
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