Daminozide
CAS No. : 1596-84-5
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
| 1g | $60 | In-stock |
| 5g | $96 | In-stock |
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| Cat. No. : | HY-13643 |
| M.Wt: | 160.17 |
| Formula: | C6H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 106.67 mg/mL (warming);H2O : 100 mg/mL (ultrasonic) |
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2]. IC50 & Target:IC50: 0.55 μM (PHF8), 1.5 μM (KDM2A), 2.1 μM (KIAA1718)[1] In Vitro: Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases)[1]. In Vivo: Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster[2].
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