Tesirine
CAS No. : 1595275-62-9
(Synonyms: SG3249)
| Size | Price | Stock |
|---|---|---|
| 1mg | $1260 | In-stock |
| 5mg | $3780 | In-stock |
| 10mg | $6050 | In-stock |
| 25mg | $9980 | In-stock |
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| Cat. No. : | HY-128952 |
| M.Wt: | 1496.65 |
| Formula: | C75H101N9O23 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity[1][2]. In Vitro:Tesirine (SG3199) is the released warhead component of the ADC payload Tesirine. Tesirine inhibits K562, NCIN87, BT474, and SKBR3 cancer cells with IC50s of 150 pM, 20 pM, 1 nM and 320 pM[1].
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