CW-069
CAS No. : 1594094-64-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $102 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $392 | In-stock |
| 100mg | $550 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15857 |
| M.Wt: | 500.33 |
| Formula: | C23H21IN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 52 mg/mL |
CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC50 of 75 μM. IC50 & Target: IC50: 75 μM (HSET)[1] In Vitro: CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM. CW-069 shows statistically significant selectivity over KSP. CW-069 potently suppresses N1E-115 cells, and less potently inhibits the NHDF cells, with IC50 of 86 ± 10 μM and 181 ± 7 μM, respectively. CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells. CW-069 (200 μM) cacuses multipolar anaphase and cell death induced in N1E-115 cells via transfection with HSET siRNA, and antagonizes inhibition of KSP by monastrol, but does not exert mitotic arrest in HeLa cells[1].
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