Etripamil
CAS No. : 1593673-23-4
(Synonyms: MSP-2017; (-)-MSP-2017)
| Size | Price | Stock |
|---|---|---|
| 5mg | $145 | In-stock |
| 10mg | $222 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $900 | In-stock |
| 250mg | $1623 | In-stock |
| 500mg | $2434 | In-stock |
| 1g | $3652 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-17611 |
| M.Wt: | 452.59 |
| Formula: | C27H36N2O4 |
| Purity: | >98 % |
| Solubility: | Ethanol : 120 mg/mL (ultrasonic) |
Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT)[1][2][3][4].
IC50 & Target:L-type calcium-channel[1].
In Vivo:Etripamil (0-0.3 mg/kg; i.v.) shows a dose-dependent decrease in systolic blood pressure, an increase in heart rate and PR interval in conscious telemetered cynomolgus monkeys[3].
Etripamil (1.9-5.7 mg/kg; intranasal administration; weekly; 26 doses) does not cause macroscopic or systemic microscopic abnormalities in cynomolgus monkeys[4].
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