L-NIL (dihydrochloride)
CAS No. : 159190-45-1
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| Cat. No. : | HY-12118 |
| M.Wt: | 260.16 |
| Formula: | C8H19Cl2N3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3]. IC50 & Target: IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3]. In Vitro: L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2]. In Vivo: L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].
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