SC57666
CAS No. : 158959-32-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $520 | In-stock |
| 10mg | $830 | In-stock |
| 25mg | $1420 | In-stock |
| 50mg | $1850 | In-stock |
| 100mg | $2400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00129 |
| M.Wt: | 316.39 |
| Formula: | C18H17FO2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. IC50 & Target: IC50: 26 nM (COX2)[1] In Vitro: SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM)[2]. In Vivo: SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1].
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