FR 167653 free base


CAS No. : 158876-65-4

158876-65-4
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Cat. No. : HY-18754
M.Wt: 427.43
Formula: C24H18FN5O2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 158876-65-4 :

FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3]. In Vivo: FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].

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