PF-06648671
CAS No. : 1587727-31-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $320 | In-stock |
| 5mg | $866 | In-stock |
| 10mg | $1300 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-120789 |
| M.Wt: | 538.92 |
| Formula: | C25H23ClF4N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease[1]. IC50 & Target:γ-secretase[1] In Vitro:In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates[1]. In Vivo:PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals[1].
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