Salvianolic acid F

Salvianolic acid F is a KRAS inhibitor, especially for KRAS G12D. Salvianolic acid F inhibits NF-kB, MMP-9, and NO simultaneously. Salvianolic acid F inhibits cancer cell growth, invasion, and migration and induces apoptosis via the EP300/PI3K/AKT pathway in vitro. Salvianolic acid F inhibits the growth of KRAS-dependent lung cancer cells via the PI3K/AKT signaling pathway in vivo. Salvianolic acid F can be used in the research of various cancers, including KRAS G12D-driven non-small cell lung cancer (NSCLC) and ovarian cancer^[1][2]. In Vitro:Salvianolic acid F (0-100 μM, 24-72 h) shows cytotoxicity against A549, OE-KRAS A549 cells, with 24 h IC₅₀s of 41.18, 36.55 μM, with 48 h IC₅₀s of 35.17, 29.33 μM, shows cytotoxicity against OVCAR-3, SK-OV-3 OC cells, with IC₅₀s of 28.89, 29.94 µM^[1][2].
Salvianolic acid F (0-40 μM, 48 h) inhibits migration and proliferation and promotes apoptosis in OE-KRAS A549, OVCAR-3, SK-OV-3 OC cells^[1][2].
Salvianolic acid F (0-40 μM, 48 h) suppresses the EP300/PI3K/AKT signaling pathway in OVCAR-3, SK-OV-3 OC cells^[2].
In Vivo:Salvianolic acid F (10-20 mg/kg, i.p., each day for 15 days) is effective in inhibiting KRAS-driven lung tumor growth by influencing the downstream PI3K/AKT pathway in A549 xenografts nude mice model^[1].
Salvianolic acid F (10-20 mg/kg, i.p., every 2 days for 40 days) inhibits lung tumor growth by influencing the downstream PI3K/AKT pathway in Kras^G12D mice model^[1].