CMF019
CAS No. : 1586787-08-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $315 | In-stock |
| 10mg | $530 | In-stock |
| 25mg | $855 | In-stock |
| 50mg | $1360 | In-stock |
| 100mg | $2040 | In-stock |
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| Cat. No. : | HY-103080 |
| M.Wt: | 455.61 |
| Formula: | C25H33N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension[1][2][3][4].
IC50 & Target:pKi: 8.58 (human Apelin receptor) ; 8.49 (rat Apelin receptor); 8.71 (mouse Apelin receptor)[1].
In Vitro:CMF019 (1-10 μM, 18 h) rescues human pulmonary arterial endothelial cells (PAEC) apoptosis induced by TNFα and CHX [4].
In Vivo:CMF019 (50-5000 nmol, 0.5 mL, i.v., three successive doses) reduces peripheral artery pressure in rats[4].
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