UU-T03
CAS No. : 1586007-00-2
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| Cat. No. : | HY-122679 |
| M.Wt: | 721.20 |
| Formula: | C37H41ClN4O9 |
| Purity: | >98 % |
| Solubility: |
UU-T03 is a β-catenin/Tcf protein-protein interaction inhibitor and an inhibitor of Wnt signaling activation. UU-T03 downregulates the expression of AXIN2, LGR5, cyclin D1, and c-myc. UU-T03 inhibits the growth of colorectal cancer cells. UU-T03 can be used for research on colorectal cancer[1][2].
In Vitro:UU-T03 (Compound 21) inhibits Wnt-responsive luciferase activity in SW480 and Wnt-activated HEK293 cells with IC50 values of 28.73 µM and 37.57 µM, respectively, without affecting FOPFlash activity[1].
UU-T03 downregulates AXIN2, LGR5, cyclin D1, and c-myc mRNA in SW480 cells in a dose-dependent manner[1].
UU-T03 (7.5-60 µM) reduced cyclin D1 and c-myc protein levels in SW480 cells without affecting β-catenin protein[1].
UU-T03 (0-60 µM) selectively disrupts β-catenin/Tcf interactions in HCT116 cells in a dose-dependent manner, without affecting β-catenin/cadherin and β-catenin/APC interactions[1].
UU-T03 inhibited the growth of SW480, HT29, and HCT116 colorectal cancer cells with IC50 values of 10.77, 11.01, and 28.83 µM, respectively, and exhibited an IC50 of 84.02 µM in normal HEK293 cells[1].
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