AM-6761
CAS No. : 1584732-36-4
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| Cat. No. : | HY-12737 |
| M.Wt: | 695.69 |
| Formula: | C33H37Cl2FN2O5S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM. IC50 & Target:IC50: 0.1 nM (MDM2)[1] In Vitro:AM-6761 is a potent inhibitor with remarkable biochemical (IC50=0.1 nM) and cellular potency (IC50=16 nM)[1]. In Vivo:AM-6761 has favorable pharmacokinetic properties.AM-6761 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 11 mg/kg[1].
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