Canfosfamide
CAS No. : 158382-37-7
(Synonyms: TLK-286; TER286)
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| Cat. No. : | HY-16124 |
| M.Wt: | 787.47 |
| Formula: | C26H40Cl4N5O10PS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies[1][2][3].
IC50 & Target:IC50: ~1 µM (DNA-PK)[3]
In Vitro: Canfosfamide (TLK-28) inhibit the catalytic kinase activity of purified DNA-dependent protein kinase (DNA-PK) with an IC50 value of ~1 µM, but causes minimal direct damage to DNA[2].
Canfosfamide (TER286) inhibits MCF-7, NIH-3T3 and M7609 in a dose-dependent manner[3].
In Vivo: Canfosfamide (TER286) exhibits more effective antitumor effect in more frequent administration[3].
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