PU139
CAS No. : 158093-65-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $71 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $495 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
| 250mg | $1460 | In-stock |
| 500mg | $2100 | In-stock |
| 1g | $2950 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-124696 |
| M.Wt: | 246.26 |
| Formula: | C12H7FN2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2].
In Vitro: PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HepG2, SW480, U-87 MG, HCT116 and SK-N-SH and MCF7 cells)[1].
PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1].
In Vivo: PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].
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