GSK2983559 (free acid)
CAS No. : 1579965-12-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $98 | In-stock |
| 10mg | $149 | In-stock |
| 25mg | $268 | In-stock |
| 50mg | $389 | In-stock |
| 100mg | $565 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112038 |
| M.Wt: | 538.53 |
| Formula: | C21H23N4O7PS2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 80°C) |
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1]. In Vitro:GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells[2]. In Vivo:GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].
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