BOS-172722
CAS No. : 1578245-44-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $330 | In-stock |
| 25mg | $660 | In-stock |
| 50mg | $990 | In-stock |
| 100mg | $1400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112162 |
| M.Wt: | 446.55 |
| Formula: | C24H30N8O |
| Purity: | >98 % |
| Solubility: | 1M HCl : 65 mg/mL (ultrasonic;adjust pH to 2 with HCl);DMSO : < 1 mg/mL |
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].
IC50 & Target: 2 nM (MPS1)[1].
In Vitro: BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer[1].
In Vivo: BOS-172722 shows excellent PK in mouse, rat, and dog[1].
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h[1].
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- Cat. No.:
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