Indinavir (sulfate)
CAS No. : 157810-81-6
(Synonyms: MK-639; L735524)
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| 100mg | $96 | In-stock |
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| Cat. No. : | HY-B0689A |
| M.Wt: | 711.87 |
| Formula: | C36H49N5O8S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 50 mg/mL (ultrasonic) |
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].
IC50 & Target: Ki: 0.54 nM (PR), 1.40 nM (PRL24I), 27.0 nM (PRI50V), 0.55 nM (PRG73S)[3].
In Vitro: Indinavir sulfate (0-50 µM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1].
Indinavir sulfate (40 µM-40 nM; 5 days) inhibits cell invasion and (40 µM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2].
In Vivo: Indinavir sulfate (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2].
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