Diroximel fumarate
CAS No. : 1577222-14-0
(Synonyms: ALKS 8700; BIIB098)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $126 | In-stock |
| 25mg | $253 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $570 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100375 |
| M.Wt: | 255.22 |
| Formula: | C11H13NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : ≥ 10 mg/mL |
Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity[1][2].
In Vivo: Diroximel fumarate (60-100 mg/kg , p.o., daily, 5 days) prevents MGO-induced mechanical and cold hypersensitivity in male and female wild-type C57BL/6 mice[2].
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