| Size | Price | Stock |
|---|---|---|
| 100mg | $60 | In-stock |
| 250mg | $145 | In-stock |
| 1g | $310 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
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Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-113081 |
| M.Wt: | 281.27 |
| Formula: | C11H15N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 116.67 mg/mL (ultrasonic) |
1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis[1][2][3]. In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells[3].
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