1-Methyladenosine


CAS No. : 15763-06-1

15763-06-1
Price and Availability of CAS No. : 15763-06-1
Size Price Stock
100mg $60 In-stock
250mg $145 In-stock
1g $310 In-stock
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Cat. No. : HY-113081
M.Wt: 281.27
Formula: C11H15N5O4
Purity: >98 %
Solubility: DMSO : 116.67 mg/mL (ultrasonic)
Introduction of 15763-06-1 :

1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis[1][2][3]. In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells[3].

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