(S)-SNAP5114
CAS No. : 157604-55-2
Price and Availability of
CAS No. : 157604-55-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $1050 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103504 |
| M.Wt: | 505.60 |
| Formula: | C30H35NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Introduction of
157604-55-2
:
(S)-SNAP5114 exhibits poor chemical stability in acidic media, with a half-life of approximately 4 h at pH 4.5[3].
The calculated log D value of (S)-SNAP5114 at pH 7.4 is close to 2, suggesting its potential blood-brain barrier penetration property[3].
(S)-SNAP5114 is a non-covalent murine GABA transporter inhibitor with blood-brain barrier penetration ability, which exhibits significant subtype-selective inhibitory activity against mGAT4 (pIC50=5.71, pKi=4.56), much higher than its effects on mGAT1, mGAT2 and mGAT3. (S)-SNAP5114 elevates extracellular GABA concentrations by blocking the GABA reuptake mechanism, thereby enhancing thalamus-specific GABAergic signaling and exerting potential neuromodulatory effects. (S)-SNAP5114 is widely used in studies related to epilepsy, neuropathic pain, anxiety and depression, and various neurodegenerative diseases[1][2][3].
IC50 & Target:IC50: 5 μM (hGAT-3), 21 μM (rGAT-2)[1].
In Vitro:(S)-SNAP-5114 (with 25 min pre-incubation) inhibits [3H]GABA uptake in HEK293 cells expressing mGAT1, mGAT3 and mGAT4, with pIC50 values of 4.07, 5.29 and 5.71, respectively; it only exhibits weak inhibitory activity against mGAT2 at a concentration of 100 μM[1].(S)-SNAP5114 exhibits poor chemical stability in acidic media, with a half-life of approximately 4 h at pH 4.5[3].
The calculated log D value of (S)-SNAP5114 at pH 7.4 is close to 2, suggesting its potential blood-brain barrier penetration property[3].
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