BTS
CAS No. : 1576-37-0
(Synonyms: N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine)
| Size | Price | Stock |
|---|---|---|
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| 5g | $90 | In-stock |
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| Cat. No. : | HY-16690 |
| M.Wt: | 261.34 |
| Formula: | C14H15NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 µM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers[1][2].
IC50 & Target: IC50: ~5 µM (skeletal muscle myosin II S1 ATPase)
In Vitro: BTS (2-12 μM) inhibits the Ca2+-stimulated ATPase activity of myosin S1 in the absence of actin, with an IC50 of ~5 µM[1].
BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM)[1].
BTS (100 μM) releases myosin from actin in the presence of ADP[1].
BTS (0-20 μM) reversibly inhibits isometric Ca2+-activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC50s of ~3 µM and 1 µM, respectively[1].
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