TX-1123
CAS No. : 157397-06-3
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| Cat. No. : | HY-121828 |
| M.Wt: | 312.40 |
| Formula: | C20H24O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].
In Vitro:TX-1123 (NIH3T3 cells) inhibits Src-K, eEF2-K, PKA, PKC, EGFR-k with IC50 values of 2.2, 3.2, 9.6, 320, and 320 μM, respectively[1].
TX-1123 (mitochondrial suspension) has a weaker mitochondrial toxicity and ATP-synthesis inhibitory activities with an IC50 value of 5 μM[1].
TX-1123 (0-1000 μM; 48 h) has antitumor activity with IC50 values of 3.66, 39, and 57 μM for HepG2, HCT116, and Rat hepatocytes, respectively[1].
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